UPB · Insider trading · 13F holders · Congress trades
Upstream Bio, Inc. (UPB)
Who is buying and selling UPB: company insiders on SEC Form 4, hedge funds and superinvestors on Form 13F, and members of Congress under the STOCK Act. Every figure links to the filing or page it comes from.
- 13F filers holding
- 7
- Insider buys, 90 days
- $0
- Insider sales, 90 days
- $28K
- Congress trades, 12 months
- 0
UPB at a glance
- Between Aug 1, 2026 and Oct 29, 2026, 5 UPB insiders filed 5 sales worth $28K on SEC Form 4, and no open-market purchases.
- 7 13F filers hold UPB among their 50 largest positions, worth $90.8M combined. The biggest bets by portfolio weight are Decheng Capital LLC (2.6%), Propel Bio Management, LLC (1.3%) and Orbimed Advisors LLC (0.7%). In their latest 13Fs, 0 managers opened a new position and 1 added to one.
- No member of Congress has disclosed a trade in UPB.
- UPB last closed at $3.27 on Oct 29, 2026.
UPB insider trading
Between Aug 1, 2026 and Oct 29, 2026, 5 UPB insiders filed 5 sales worth $28K on SEC Form 4, and no open-market purchases.
| Filed | Insider | Role | Trade | Shares | Price | Value | Form 4 |
|---|---|---|---|---|---|---|---|
| Sep 17, 2026 | Sutherland Everett Rand | Chief Executive Officer, Director | Sale | 2,095 | $5.49 | $12K | SEC |
| Sep 17, 2026 | Deykin Aaron | Chief Medical Officer | Sale | 895 | $5.49 | $5K | SEC |
| Sep 17, 2026 | Gray Michael | CFO and COO | Sale | 853 | $5.49 | $5K | SEC |
| Sep 17, 2026 | Houghton Adam | Chief Business Officer | Sale | 700 | $5.49 | $4K | SEC |
| Sep 17, 2026 | Ambrose Allison | General Counsel | Sale | 485 | $5.49 | $3K | SEC |
Who owns UPB? Hedge funds and superinvestors
7 13F filers hold UPB among their 50 largest positions, worth $90.8M combined. The biggest bets by portfolio weight are Decheng Capital LLC (2.6%), Propel Bio Management, LLC (1.3%) and Orbimed Advisors LLC (0.7%). In their latest 13Fs, 0 managers opened a new position and 1 added to one.
| Manager | % of portfolio | Value | Shares | Last quarter | 13F |
|---|---|---|---|---|---|
| Orbimed Advisors LLCHedge fund | 0.7% | $39.4M | 5,693,589 | +0.0% shares | Q2 2026 |
| Decheng Capital LLCHedge fund | 2.6% | $18.9M | 2,724,868 | +0.0% shares | Q2 2026 |
| Enavate Sciences Gp, LLCInvestment manager | 4.9% | $17.0M | 2,459,703 | +0.0% shares | Q2 2026 |
| Parkman Healthcare Partners LLCHedge fund | 0.7% | $6.5M | 935,247 | +18.9% shares | Q2 2026 |
| Bain Capital Life Sciences Investors, LLCAsset manager | 0.2% | $4.2M | 600,949 | -30.7% shares | Q2 2026 |
| Samsara Biocapital, LLCHedge fund | 0.2% | $2.4M | 353,717 | -51.9% shares | Q2 2026 |
| Propel Bio Management, LLCHedge fund | 1.3% | $2.4M | 350,389 | +2.5% shares | Q2 2026 |
Each manager counts with its latest 13F (Q2 2026: 7). Screen UPB in the grand portfolio →
UPB stock trades by members of Congress
No member of Congress has disclosed a trade in UPB.
UPB questions and answers
Are insiders buying UPB stock?
Between Aug 1, 2026 and Oct 29, 2026, 5 UPB insiders filed 5 sales worth $28K on SEC Form 4, and no open-market purchases.
Which hedge funds own UPB?
7 13F filers hold UPB among their 50 largest positions, worth $90.8M combined. The biggest bets by portfolio weight are Decheng Capital LLC (2.6%), Propel Bio Management, LLC (1.3%) and Orbimed Advisors LLC (0.7%). In their latest 13Fs, 0 managers opened a new position and 1 added to one.
Has Congress traded UPB?
No member of Congress has disclosed a trade in UPB.
Who is the largest holder of UPB?
Among 13F filers, Orbimed Advisors LLC reports the largest UPB position, $39.4M (5,693,589 shares) in its Q2 2026 13F. The biggest bet by portfolio weight is Decheng Capital LLC's: 2.6% of its portfolio.
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